The inferior colliculus is involved in deviant sound detection as revealed by BOLD fMRI

Rapid detection of deviant sounds is a crucial property of the auditory system because it increases the saliency of biologically important, unexpected sounds. The oddball paradigm in which a deviant sound is randomly interspersed among a train of standard sounds has been traditionally used to study this property in mammals. Currently, most human studies have only revealed the involvement of cortical regions in this property. Recently, several animal electrophysiological studies have reported that neurons in the inferior colliculus (IC) exhibit reduced responses to a standard sound but restore their responses at the occurrence of a deviant sound (i.e., stimulus-specific adaptation or SSA), suggesting that the IC may also be involved in deviance detection. However, by adopting an invasive method, these animal studies examined only a limited number of neurons. Although SSA appears to be more prominent in the external cortical nuclei of the IC for frequency deviant, a thorough investigation of this property throughout the IC using other deviants and efficient imaging techniques may provide more comprehensive information on this important phenomenon. In this study, blood-oxygen-level-dependent (BOLD) fMRI with a large field of view was applied to investigate the role of the IC in deviance detection. Two sound tokens that had identical frequency spectrum but temporally inverted profiles were used as the deviant and standard. A control experiment showed that these two sounds evoked the same responses in the IC when they were separately presented. Two oddball experiments showed that the deviant induced higher responses than the standard (by 0.41±0.09% and 0.41±0.10%, respectively). The most activated voxels were in the medial side of the IC in both oddball experiments. The results clearly demonstrated that the IC is involved in deviance detection. BOLD fMRI detection of increased activities in the medial side of the IC to the deviant revealed the highly adaptive nature of a substantial population of neurons in this region, probably those that belong to the rostral or dorsal cortex of the IC. These findings highlighted the complexity of auditory information processing in the IC and may guide future studies of the functional organizations of this subcortical structure.